2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-111306
    ATL-802 847612-12-8 98%
    ATL-802 is a potent adenosine A2B receptor antagonist. ATL-802 is promising for research of diabetes.
    ATL-802
  • HY-111523
    Isomahanine 144606-95-1 98%
    Isomahanine, carbazole alkaloid, is an antioxidative agent. Isomahanine has DPPH radical scavenging activity with an IC50 value of 24 μM.
    Isomahanine
  • HY-111583
    RXFP3/4 agonist 1 2351104-40-8 98%
    RXFP3/4 agonist 1 is an agonist of relaxin family peptide 3/4 receptor (RXFP3/4), with EC50s of 82/2 nM, respectivley. RXFP3/4 agonist 1 increases food intake in rats.
    RXFP3/4 agonist 1
  • HY-112527
    7(Z),11(Z)-Heptacosadiene 100462-58-6 98%
    7(Z),11(Z)-Heptacosadiene is an ester product.
    7(Z),11(Z)-Heptacosadiene
  • HY-112540
    Acetoacetic acid 541-50-4 98%
    Acetoacetic acid is an oxidative stress inducer that affects the antioxidant enzyme system and lipoprotein metabolism. Acetoacetic acid induces oxidative stress by decreasing the mRNA expression and activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), increasing MDA content, and inhibiting very low density lipoprotein (VLDL) assembly by downregulating apolipoprotein ApoB100, ApoE, and low density lipoprotein receptor (LDLR), leading to triglyceride (TG) accumulation in hepatocytes. Acetoacetic acid can be used to study metabolic diseases.
    Acetoacetic acid
  • HY-113033
    Pentosidine 124505-87-9 98%
    Pentosidine is an advanced glycation end product (AGE) and cross-linked substance with fluorescent properties. Pentosidine is present in various human tissues and can serve as a biomarker for diabetes, aging, uremia, protein accumulation damage, and non-enzymatic modification of long-lived proteins in the Maillard reaction. It aids in gaining a deeper understanding of the overall role of the Maillard reaction in aging and disease.
    Pentosidine
  • HY-113049
    Phosphoenolpyruvic acid 138-08-9 98%
    Phosphoenolpyruvic acid (Phosphoenolpyruvate) is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid also exhibits cytoprotective and anti-oxidative properties.
    Phosphoenolpyruvic acid
  • HY-113077
    9-Hydroxy-10(E),12(E)-octadecadienoic acid 115185-06-3 98%
    9-Hydroxy-10(E),12(E)-octadecadienoic acid ((10E,12E)-9-Hydroxyoctadeca-10,12-dienoic acid) is an ester product.
    9-Hydroxy-10(E),12(E)-octadecadienoic acid
  • HY-113125
    Dolichol-20 2067-66-5 98%
    Dolichol-20 is an ester product.
    Dolichol-20
  • HY-113149
    Argininosuccinic acid 2387-71-5 98%
    Argininosuccinic acid is an intermediate metabolite in the urea cycle, and its level is associated with argininosuccinic aciduria. Argininosuccinic acid can induce oxidative stress, leading to lipid and protein oxidation, reduction of glutathione, and decrease in antioxidant enzyme activity. Argininosuccinic acid can be converted into guanidinosuccinic acid, a nitric oxide mimic, under the action of nitric oxide-derived free radicals. Argininosuccinic acid can be used in the research of metabolic diseases, renal failure, nervous system diseases, etc.
    Argininosuccinic acid
  • HY-113401
    Adenosine 2',3'-cyclic phosphate 634-01-5 98%
    Adenosine 2',3'-cyclic phosphate is a 2',3'-cyclic purine nucleotide. Adenosine 2',3'-cyclic phosphate can be degrade to 2'-AMP and 3'-AMP.
    Adenosine 2',3'-cyclic phosphate
  • HY-113407
    D-Fructose-6-phosphate 643-13-0 98%
    D-Fructose 6-phosphate is an endogenous metabolite in saliva that affects cell growth and autophagy; it can be hydrolyzed by Fructose-1,6-bisphosphatase (FBPase). D-Fructose-6-phosphate can be converted into D-glucose 6-phosphate (HY-112537) by the action of phosphoglucose isomerase. D-Fructose-6-phosphate is a sugar intermediate in the glycolysis pathway and the pentose phosphate pathway. D-Fructose 6-phosphate can be used to study Lewy body dementia.
    D-Fructose-6-phosphate
  • HY-113510
    9(S)-HOTrE 89886-42-0 98%
    9(S)-HOTrE is an ester product.
    9(S)-HOTrE
  • HY-113545
    9(R)-HODE 10075-11-3 98%
    9(R)-HODE is a monohydroxy fatty acid and metabolite of linoleic acid. It is formed from linoleic acid by COX and lipoxygenase (LO).9(R)-HODE induces chemotaxis, increases the levels of chemokine (C-C motif) receptor 9 (CCR9) and chemokine (C-X-C motif) receptor 4 (CXCR4), and inhibits IL-6 release in primary human monocytes. It inhibits CD3α- and CD28-induced proliferation of isolated human peripheral blood lymphocytes when used at a concentration of 25 μg/mL.
    9(R)-HODE
  • HY-113553
    4-Aminophenylphosphorylcholine 102185-28-4
    4-Aminophenylphosphorylcholine ((p-Aminophenyl)phosphocholine) is a probe that can be conjugated to agarose gels to generate adsorbents for affinity precipitation experiments.
    4-Aminophenylphosphorylcholine
  • HY-113567
    GSK2324 1020567-30-9 98%
    GSK2324 (Compd 1c) is a FXR agonist for diabetes study, with an EC50 of 120 nM. GSK2324 exhibits t1/2 values of 84 min (mouse), 170 min (rat), 110 min (beagle) and 120 min (cyno), respectively.
    GSK2324
  • HY-113655
    AD-5075 103788-05-2 98%
    AD-5075 is an orally active insulin sensitizer. AD-5075 mediates its antidiabetic activity by binding to PPARγ and thereby generating an active conformation of the receptor.
    AD-5075
  • HY-113775
    Octadecanoyl-L-threo-sphingosine 95037-06-2 98%
    Octadecanoyl-L-threo-sphingosine is an ester product.
    Octadecanoyl-L-threo-sphingosine
  • HY-113820
    AZD4619 1067247-60-2 98%
    AZD4619 is an orally active, selective peroxisome proliferator-activated receptor α (PPARα) agonist. AZD4619 increases alanine aminotransferase 1 (ALT1) protein expression in a dose-dependent manner in human, but not in rat primary hepatocytes. AZD4619 is a lipid-lowering drug.
    AZD4619
  • HY-113836
    3-Hydroxyhexanoic acid 10191-24-9 98%
    3-Hydroxyhexanoic acid is an ester product.
    3-Hydroxyhexanoic acid
Cat. No. Product Name / Synonyms Application Reactivity